Human fat cell lipolysis is primarily regulated by inhibitory modulators acting through distinct mechanisms.

Human fat cell lipolysis is primarily regulated by inhibitory modulators acting through distinct mechanisms.

The effects of adenosine deaminase and of pertussis toxin on hormonal regulation of lipolysis were investigated in isolated human fat cells. Adenosine deaminase (1.6 micrograms/ml) caused a two-to threefold increase in cyclic AMP, which was associated with an increase in glycerol release averaging 150-200% above basal levels. Clonidine, N6-phenylisopropyladenosine, prostaglandin E2, and insulin...

CD4(+)CD25(+) T-cell development is regulated by at least 2 distinct mechanisms.

It has recently been shown that CD4(+)CD25(+) T cells are immunoregulatory T cells that prevent CD4(+) T-cell-mediated organ-specific autoimmune diseases. In this study, the regulatory mechanism of CD4(+)CD25(+) T-cell development were investigated using T-cell receptor (TCR) transgenic mice. It was found that CD4(+)CD25(+) T cells preferentially expressed the endogenous TCRalpha chain in DO10(...

CD41CD251 T-cell development is regulated by at least 2 distinct mechanisms

It has recently been shown that CD41CD251 T cells are immunoregulatory T cells that prevent CD41 T-cell–mediated organ-specific autoimmune diseases. In this study, the regulatory mechanism of CD41CD251 T-cell development were investigated using T-cell receptor (TCR) transgenic mice. It was found that CD41CD251 T cells preferentially expressed the endogenous TCRa chain in DO101 TCR transgenic mi...

Somatostatin and parvalbumin inhibitory synapses onto hippocampal pyramidal neurons are regulated by distinct mechanisms.

Excitation-inhibition balance is critical for optimal brain function, yet the mechanisms underlying the tuning of inhibition from different populations of inhibitory neurons are unclear. Here, we found evidence for two distinct pathways through which excitatory neurons cell-autonomously modulate inhibitory synapses. Synapses from parvalbumin-expressing interneurons onto hippocampal pyramidal ne...

Inhibitory Fcg Receptor Is Required for the Maintenance of Tolerance through Distinct Mechanisms